Consensus configurational bias Monte Carlo method and system for pharmacophore structure determination

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The Curagen Corporation patent solves the following problem:

Protein interactions lately emerged as a fundamental target for medicinal intervention. For example, the first two major uncured disease in the United States is atherosclerosis (the main cause of heart attack and stroke) and cancer. These diseases are responsible for greater than 50% of all US mortality and costs the US economy $ 200 billion per year. A consistent picture of this disease, which gradually emerged in the past ten years the molecular biological and medical research, view and triggered the disordering of specific molecular events to their place among the set of proteins in both normal and disease states.

Our analysis of this patent is as follows:

Curagen Corporation’s patent US 6341256 B1 deals with Consensus configurational bias Monte Carlo method and system for pharmacophore structure determination.
In a particular image, this invention includes a method for determining an accurate, consensus pharmacophore structure shared with compounds that bind selectively to a target molecule. Optionally, the method began screening a diversity library against the target molecule of interest in getting to selectively binds members. After the framework of selected members of the samples and a candidate pharmacophore responsible for binding to the target molecule determined. Next, preferably by REDOR nuclear magnetic resonance, with some very accurate interatomic distance determined in some selected members of the relevant pharmacophore candidate. A very proper consensus, configurational bias Monte Carlo method determination candidate pharmacophore structure made using the framework of selected members and the use of such constraints shared candidate pharmacophore and some measured distances. This determination adapted to efficiently inspect only relatively minor form of energy as about any structural constraint now organic diversity library. If the diversity library includes short peptide, the determination respect to known degrees of freedom of the peptide as well as any internal constraints, such as those imposed by disulfide bridges. In the end, the very accurate pharmacophore as determined using lead in choosing organics for drug development target in the initial target molecule.

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Surface mountable low IMD ferrite isolator/circulator structure

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The Renaissance Electronics Corporation patent solves the following problem:

The increased demand from the communication industry to provide greater channel capacity with the additional power requirements revealed in a state in RF structures aimed at Intermodulation distortion (IMD). This situation occurs when non-linearity in the building, especially in the lead part, distort the waveform has resulted in the generation of other frequency that effectively block the channel. In other words, the distorted waveform has constituted the desired basic plus a rotten series of relevant harmonics, themselves, associate with other carriers now in line transmission. Intermodulation signal grow rapidly with power, and power tends to increase. Cellular telephone communication, for example, maximum emission power as high as 30 Watts. In some applications it may be even 50 watts and over. The reduction in nonlinear intermodulation noise Hence the importance, not only to improve the signal quality, but also to allow fewer radio stations distributed in the network transmission. The above is the first part that should be taken into consideration isolator / circulator designs.

Our analysis of this patent is as follows:

Renaissance Electronics Corporation’s patent US 6337607 B1 deals with Surface mountable low IMD ferrite isolator/circulator structure.
A framework for a high power low IMD passive microwave devices, mainly for automated placement. structure includes a substantially flat housing with slots and a cover with notches. Slots and notches form openings snugly receive printed circuit board (PCB) with signal transmission lines on both sides. Also, on both sides of the PCB against the signal line, the ground plane is located. The passive devices that between the housing and the cover, and electricity connected to the line to signal transmission within the framework that is completely closed and firm. Bottom surface of the PCB and the housing coplanar. PCB added on both sides of the supporters came from housing. The structure provides a consistent leader and the best conditions for automated placement. Inductance balance good signal line capacitance to ground planes in combination with structurally consistent leadership provided under IMD. Emittance RF field of high power passive device into the environment is negligible because of the completely closed structure.

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Method of exposure, photomask, method of production of photomask, microdevice, and method of production of microdevice

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The Nikon Corporation patent solves the following problem:

Our analysis of this patent is as follows:

Nikon Corporation’s patent US 6337162 B1 deals with Method of exposure, photomask, method of production of photomask, microdevice, and method of production of microdevice.
A method of exposure projecting and exposing a pattern formed on a mask to a photosensitive substrate through a projection optical system, comprising the steps of measuring a position of an image estimated in said projection optical system; and projecting and exposing said pattern mask in a state of imaging characteristics id to reduce the amount of offset in a position to said project images from an ideal position.

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