Methods and systems for analyzing and determining ligand-residue interaction

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The Locus Pharmaceuticals, Inc. patent solves the following problem:

The present invention relates to computer-implemented methods and systems to analyze the interaction between the peptide amino acid residues and one or more molecular fragments. the invention further provides methods and systems using information about the particle-polypeptide interaction to help in drug design.

Our analysis of this patent is as follows:

Locus Pharmaceuticals, Inc.’s patent US 7415361 B2 deals with Methods and systems for analyzing and determining ligand-residue interaction.
A method implemented in the form of a computer simulation code for evaluating the free energy of binding between the polypeptide amino acid residues and one or more molecular fragments presented. The basis of the strategy is a novel weighted Metropolis Monte Carlo method for the sampling of the canonical ensemble. By making use of the property in the grand canonical ensemble, the affinity of fragments to bind in the vicinity of each protein residue can be efficiently computed. The seal number associated with each particle residue paris estimated on the basis of a simple criteria closeness, and a useful affinity mapping of surface proteins can be obtained in this way. The analysis of these data for various particle species provides valuable information to help identify the protein binding sites, as well as identify key pieces used for the construction of potential led drug.

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Image forming apparatus with setting of an operating condition of at least one image heating device

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The Canon Kabushiki Kaisha patent solves the following problem:

Our analysis of this patent is as follows:

Canon Kabushiki Kaisha’s patent US 7412182 B2 deals with Image forming apparatus with setting of an operating condition of at least one image heating device.
An image forming system has an image forming device, a first heating device for heating a toner image of a first break to maintain a target temperature, a second image heating device for heating a toner image of a second break to maintain a target temperature, a selection device for selecting a first image building strategy that only the first heating device used for a heating process the image and a second image formation means that the first image heating device and the second image heating device used for heating process, and a long wait to make a time when the target temperature the first heating device is lowered to a position in the state after a period in which the target temperature second heating device that lowered the standing state.

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Object oriented library for Markov chain Monte Carlo simulation

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The Battelle Memorial Institute patent solves the following problem:

The present invention relates in general to the Markov chain Monte Carlo (MCMC) analysis and more specifically to systems, methods and computer implemented tools for doing MCMC simulations.

Our analysis of this patent is as follows:

Battelle Memorial Institute’s patent US 7409325 B2 deals with Object oriented library for Markov chain Monte Carlo simulation.
Systems, methods and computer implemented tool given for work in Markov chain Monte Carlo simulations. Computer implemented tools include a library MCMC class represents a core foundation of the MCMC analysis that minimizes the knowledge of computer programming and overseeing the overhead associated with the implementation of the MCMC simulation. Furthermore, a user interacting with the various embodiments of the present invention given volume control on the issue that a skilled user can run successfully MCMC simulations wherever components distribution interest in the non-standard.

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Variable resistance pulmonary ventilation bypass valve and method

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The Portaero, Inc. patent solves the following problem:

The present invention relates to devices for treating diseased lungs, and more particularly, to a device for controlling the flow of air vented from predetermined areas in the lung or lung .

Our analysis of this patent is as follows:

Portaero, Inc.’s patent US 7406963 B2 deals with Variable resistance pulmonary ventilation bypass valve and method.
A collateral ventilation bypass trap system directly involved in the lungs of a patient or tumor can be used to increase the expiratory flow from the diseased lung or lungs, as a treat of chronic obstructive pulmonary disease . The system includes a snare, a filter / one-way valve, an air carrying conduit and a retention device for taking elements of the system in position. the system also includes a flow restriction device for controlling the flow of air through the air carrying canal.

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Index to a semi-structured database

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The British Telecommunications Public Limited Company patent solves the following problem:

Then, there are two major ways to enjoy the data stored in electronic format. The first process is known as information retrieval and operates on a strict procedure poison search. So, if a user were to enter a question in the form of a keyword, using information retrieval techniques, the entire database is searched for a string that matches the keyword. Clearly, such a system suffers from the drawback that they can not attend the relevant entries must be the form of words in the database differ slightly in the form of keywords. this problem can be overcome by using a by techniques that the key word is truncated and a global word ever further. But again it suffers from the drawback that many important records may be located involving similar keywords.

Our analysis of this patent is as follows:

British Telecommunications Public Limited Company’s patent US 7409381 B1 deals with Index to a semi-structured database.
A method and apparatus for creating an index entry for a record in a semi-structured database includes analyzing each field to identify an entry in each country and to identify a set of characters with a format corresponding to a predetermined format. Thereafter, the method and apparatus operate to create an index entry for the recognized when, and for at least one field, identifying any character that is not recognized as an entry as a free text entry.

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Method of using RFID systems to help blind and visually-impaired individuals

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The International Business Machines Corporation patent solves the following problem:

The present invention is directed generally to Radio Frequency Identification (RFID) system. More particularly, the present invention is directed to an apparatus, system and method of using RFID systems to help blind and / or visually-impaired individuals function in a modern society without the help of staff and dog seeing-eye.

Our analysis of this patent is as follows:

International Business Machines Corporation’s patent US 7408465 B2 deals with Method of using RFID systems to help blind and visually-impaired individuals.
An apparatus, system and method of using RFID systems to help blind and visually-impaired individuals to act efficiently in society without the use of staff, and / or seeing-eye dog given. Usually, everything may include an RFID tag affixed to it. tag includes the information needed to help a blind or visually-impaired individuals. The individual can create a profile in which the individual may show the way for use to convey information. It is expected that each carry a battery-operated RFID reader to read information from RFID tags and interpreting information as to convey the profile shown.

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