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The Robert Charles Ladner patent solves the following problem:
It is now common practice in the art to prepare libraries of genetic packages that each display, display and express, or comprise a member of a different family of peptides, polypeptides or proteins and general display, display and express, or comprise at least a portion of amino acid differences in the family. In many common libraries, peptides, polypeptides or proteins associated with the antibody (eg, single chain Fv (scFv), Fv, Fab, whole antibodies or minibodies (ie, dimers consisting VH linked with VL)). Usually, they comprise one or more of the CDRs and framework regions of the heavy and light chains of human antibodies.
Our analysis of this patent is as follows:
Robert Charles Ladner’s patent US 8895475 B2 deals with Focused libraries of genetic packages.
Focus library vector or gene packages that display, display and express, or comprise a member of a different family of antibody peptide, polypeptides or proteins and collectively display, display and express, or covers at least one of the focuses difference in families. The library of elevation and in the manner that mimic that found in native human antibodies.
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