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The Pola Chemical Industries Inc. patent solves the following problem:
For example, the pigmentation, freckle, melasma, and senile lentigo, which causes the skin after suntan, living in such a state that the melanin production was held for the activation of pigment cells (melanocytes ) skin. The component, known as the function of preventing or ameliorating the onset and deterioration of the skin pigment disorder as described above, the compound (skin whitening agent) with skin whitening function including, for ex- example, ascorbic acid derivatives, hydrogen peroxide, colloidal sulfur, glutathione, hydroquinone, and catechol (see, for example, Non-Patent Document 1 and Non-Patent Document 2). Besides preparations for the skin, which is blended with components as described above as the active ingredient, are widely used. Today, a variety of mechanisms of action to report as to the mechanism of action belonging to the compound known as the skin whitening agents, including, for example, the tyrosinase enzyme inhibiting action, tyrosinase-related protein in shame, and the melanin transfer ban for the suppression of dendrite elongation in melanocyte. Target molecules are with respect to the respective mechanisms of action. To declare the high skin whitening effect, an organic low molecular weight compound, which appropriately interact with target molecules, useful. Furthermore, the organic low molecular weight compound, which appropriately interact with each of the target molecule, has structural characteristics that differ depending on each of the target molecule. Therefore, the study did so strongly in relation to the optimization of the chemical structure to maximally make use of the medical action showed the organic low molecular weight compound. Today, the study of skin whitening agents is not limited to compound with high efficiency and high selectivity with respect to the current target molecules, study and expanded, for example, the compound act together in a plural skin whitening target molecule and the compound has a novel mechanism of action. The high skin whitening action expected for skin whitening agents as described above. In fact, the screening is carried out in relation to the compounds have excellent skin whitening functions while seeking for useful compounds of various chemical structures or medicinal qualities. Any skin whitening agent, has a novel scaffold, said until now.
Our analysis of this patent is as follows:
Pola Chemical Industries Inc.’s patent US 9066914 B2 deals with Prophylactic or ameliorating agent for pigmentation.
One thing the present invention is to provide a prophylactic or ameliorating agent for natural color with a novel pulpit and an external preparation for skin containing the same as a component. something achieved by providing a prophylactic or ameliorating agent for natural color contains a compound represented by the following general formula (1), an isomer thereof, and / or a pharmacologically acceptable salt thereof, and an external preparation for skin containing the same as a component: [wherein R1 represents a hydrogen atom or a linear or branched chain alkyl group 1 to 8 carbon (s) atoms; R2 represents a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 8 carbon (s) atoms, a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic groups, or a substituted or unsubstituted heterocyclic group having a 5 to 12 carbon atoms; P3 represents a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 15 carbon atoms; n represents an integer of 1 or 2; and m represents an integer of 0 to 3.]
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