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The Shionogi & Co., Ltd. patent solves the following problem:
To date, a type of beta-lactam drugs and beta-lactam drugs were clinically very important antimicrobial drugs. However, there are increasing number of bacteria species have resistancy against beta-lactam drugs by producing beta-lactamase, which degrade beta-lactam drugs. According to Ambler molecular classification, beta-lactamase most classified into four classes. Specifically, the Class A (TEM, SHV, CTX-M type and the like), Class B (IMP range, vim, L-1 and the like), Class C (AMPC type) and Class D (OXA type and the like). Among them, class A, C and D forms that generally are classified into Serine-beta-lactamase, and on the other hand, Class B species are classified into metallo-beta-lactamase. It is known that both have every different mechanisms to one another in terms of the hydrolysis of the beta-lactam drugs.
Our analysis of this patent is as follows:
Shionogi & Co., Ltd.’s patent US 9145425 B2 deals with Cephem compound having catechol group.
This creation has Cephem compounds of formula: or an Ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof, a pharmaceutical composition, and a method for the treatment of bacterial infectious diseases with the compound, Esther, the protected compound, salt, or solvate thereof, wherein the symbols in the formula described in the specification. The compounds exhibit potent antimicrobial spectrum against a variety of bacteria, including gram negative bacteria and / or programs positive bacteria, preferably the beta-lactamase producing programs negative bacteria, more preferably, multi-drug resistant microbials, in particular, Class B type metallo-beta- lactamase program negative bacteria, and still the best extended-spectrum beta-lactamase (ESBL) bacteria. The compounds most preferably not show cross-resistance against known Cephem carbapenem drugs or drugs.
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