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The New York University patent solves the following problem:
Natural saccharide-binding proteins, including lectins and Periplasmic substrate-binding protein, the use of water desolvation, hydrogen bonding (H-bonding), and CH partnership to selectively identify glycans may be different in orientation in a group hydroxyl achieve cost affinities, Kas, as high at 106 M1 (NEED with Glycobiology (Ajit Varki et al eds, Cold Spring Harbor Laboratory Press, 1999); BEAT ERNST et al, carbohydrates chemistry UG biology PART II .. biology of saccharides (Wiley-VCH. 2000); Ambrosi et al, org Biomol Chem 3: …. 1593-1608 (2005); Toone, Curr Opin Biol building 4: …. 719-728 (1994); Lemieux, Acc Chem Res 29: 373-380 (1996)). Selected carbohydrate recognition artificial cells remains a major area of investigation for the challenge of differentiating between molecules in subtle structural differences, their ability to express the basic aspects of saccharide binding, and some potential applications for disease detection, therapy, or catalysis (Davis,. org Biomol Chem 7: 3629-3638 (2009); Davis & Wareham, Angew Chem Int Ed 38: 2978-2996 (1999); Mazik RSC adv 2: …. 2630-2642 (2012) ;. Mazik, Chem Soc Rev 38: 935-956 (2009); Kubik, Angew Chem Int Ed 48: ……. 1722- 1725 (2009); Jin et al, Med Res Rev 30: 171 -257 (2010); Walker et al, Cell mol Life Sci 66: 3177-3191 (2009)) ….. these two receptor using covalent and noncovalent interactions stabilize complexation. For example, change the reactions of boronic acid to syn-diols successfully used to selectively bind sugars, such as glucose and ribose, and sugar alcohols, such as sorbitol and mannitol (Jin et al, Med Res Pin 30: 171-257 (2010); Tony D. JAMES et al, boronic acid sA saccharide PAG-ILA (the Royal Society of Chemistry 2006); James et al, Angew Chem Int Ed 35: ….. . 1910-1922 (1996)), but the recognition of monosaccharides holding axial hydroxyl groups, such as mannose, remained challenging in this way. On the other hand, by following the principles of electronic cram in complementarity and structural preorganization (DJ cram & JM fill, Container molecules and their guests (The Royal Society of Chemistry 1997); Artz & cram, J. Am Chem Soc 106: 2160-2171 …. (1984); cram et al, J. Am Chem Soc 103: 6228-6232 (1981); DJ JM cram and cram, ACC Chem Res 11: 8- 14 (1978)), the molecules that bind created by the noncovalent association and do not distort the sealing importance. In these receptor, identify groups of rigidly position in three dimensional space, such as natural lectins (Weis & Drickamer, Annu Rev Biochem 65: 441-473 (1996) ), to overcome the entropy-enthalpy fee which any favorable enthalpic changes that arise from the formation of noncovalent bonds offset the entropically undesirable reduction in the internal actions of the army and the sealing visitors (Liu & Guo, Chem Rev 101 :. 673-695 (2001)).
Our analysis of this patent is as follows:
New York University’s patent US 9296688 B2 deals with Carbohydrate-selective receptors.
The present invention is directed to a new class of synthetic carbohydrate receptor compounds comprising Formula I as described herein: (i). The other part of the present invention relates to pharmaceutical compositions and pharmaceutical delivery vehicles containing the compound of Formula (I) The present invention is also directed to methods of treatment and diagnosis, which involves the administration of a compound Formula (I).
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