Nucleic acid molecules encoding antibodies which bind CCR4 and uses thereof

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The Cancer Research Technology Limited patent solves the following problem:

With more than 800 members, G-protein-coupled receptor (GPCRs) represent the largest family of cell surface molecules involved in signal transmission, accounting for 2% of the total gene encoded human genome. The members of the GPCR share a common membrane Topology: an extracellular N-terminus, an intracellular C-terminus and seven transmembrane (TM) helices connected by three intracellular loops and three extracellular loops. On the basis of their shared topological structure, GPCRs are also referred to as seven transmembrane (7tm) receptor. These receptors control key physiological functions, including neurotransmission, hormone and enzyme release from endocrine and exocrine glands, immune responses, cardiac- and smooth-muscle and blood pressure regulation. Their dysfunction contributes to some of the most widespread human diseases. Emerging experimental and clinical data showed that GPCRs have an important role in cancer growth and metastasis. Therefore, the possibility exists that some GPCRs could be target for anti-cancer drugs.

Our analysis of this patent is as follows:

Cancer Research Technology Limited’s patent US 9458238 B2 deals with Nucleic acid molecules encoding antibodies which bind CCR4 and uses thereof.
The present invention provides antibodies that bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and that is capable of inhibiting the binding of macrophage-derived chemokine (MDC) and / or thymus and activation regulated chemokine (TARC) CCR4. Also provides inter alia immunoconjugates and compositions comprising these antibodies and methods and uses involving the same antibody, particularly in the medical and diagnostic fields.

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