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The Duke University patent solves the following problem:
Therapeutic proteins or peptides in their native state or when recombinantly produced a labile molecules demonstrate, inter alia, short periods of serum stability, serum half-life (ie, circulation half-life ), or limited Persistance body. Such molecules can also be extremely labile when formulated, as when formulated in aqueous solution.
Our analysis of this patent is as follows:
Duke University’s patent US 9458218 B2 deals with Therapeutic agents comprising fusions of insulin and elastic peptides.
The present invention provides therapeutic agents and compositions comprising elastic therapeutic peptides and proteins. Such peptide exhibit a flexible, extended conformation. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist (eg, GLP-1, exendin), insulin, or Factor VII / VIIa, including functional analogs. The present invention further provides polynucleotides encoding, as well as methods of making and using therapeutic agents. The therapeutic agent is improvement in relationship to their use as therapeutics, including, inter alia, one or more of the half-life, clearance and / or body Persistance, solubility, and bioavailability.
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