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The Merck & Co., Inc. patent solves the following problem:
Drug-induced thrombocytopenia contribute to disease and, sometimes, the mortality in patients treated with a wide range of medicines (Karpatkin, (1971) Am. J. Med. Sci. 262, p. 68). Over 100 different drugs involved in drug-induced thrombocytopenia, including heparin, quinine, quinidine and sulfonamide antibiotics (Shulman et al. Hemostasis and thrombosis (ed 2) Philadelphia, Pa., Lippincott (1987) p .452, and Kracke et al. (1943) JAMA 122, p. 168.
Our analysis of this patent is as follows:
Merck & Co., Inc.’s patent US 6210904 B1 deals with Anticoagulant test.
The present invention is a method for diagnosing a patient at risk of thrombocytopenia induced by administration of a GP IIb / IIIa receptor antagonists, comprising combining i) a plasma sample of the patient; ii) detect monoclonal antibody they encourage cost areas formed the GP IIb / IIIa receptor association following a fibrinogen receptor antagonists of GP IIb / IIIa receptor; and iii) GP IIb / IIIa receptor: GP IIb / III receptor complex enemy, and determine associations with detectable monoclonal antibody with the complex in the presence of plasma.
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