Dispensing device with displacement detection

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The Abiogenix Inc. patent solves the following problem:

Healthcare is implemented as an open-loop system. Patients diagnosed with a doctor and prescribed treatment. However, there are not many reliable systems to be able to monitor if patients comply with or follow the instructions given by the doctor. Studies show that when patients stop taking their medication for three days, they are unlikely to continue their regimen.

Our analysis of this patent is as follows:

Abiogenix Inc.’s patent US 9456959 B2 deals with Dispensing device with displacement detection.
Embodiments generally relate to a pill box adapted to provide treatment. In one embodiment, the pill box includes a base member, a carousel with a base member and configured to rotate about the base, one or more chambers, each chamber formed in carousel and configured to store a single dose of medication with a lid configured to enclose the base and the carousel. The pill box ratchet growth mechanism includes a strong member and a stop member configured to perform motion carousel in a first direction and to restrict motion in a second direction, and a locking component configured to allow a pre-determined eviction ACCOUNT in the first direction and to limit further displacement in the first direction by locking the carousel.

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Method for inducing cell death in acute lymphoblastic leukemic system cells

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The Cantargia Ab patent solves the following problem:

Chronic myeloid leukemia (CML) is the first human neoplasm associated with a recurrent genetic aberration; Philadelphia (Ph) chromosome, formed by a corresponding transition between chromosome 9 and 22, giving rise to a constitutively activated tyrosine kinase BCR / ABL11. In CML, Ph chromosome is believed to originate from a hematopoietic stem cell (HSC) as it clonally found in malignant myeloid cells and non-malignant lymphoid cells2. The Ph chromosome is found in a part of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). CML composed of heterogeneous cell in various stages maturation maintained by a small number of cells, called CML stem cells, sharing the capacity of self-renewal of normal HSC3 . This shows that CML stem cells at least partially resistant to current treatments tyrosine kinase inhibitors4,5, despite clinical success demonstrated a suppressive rather than curative effects of this disease. Therefore, recognition of a way to efficiently target CML stem cells very attractive to achieve a permanent cure for the disease. Such a strategy to identify a target in CML stem cells provide a novel means to eliminate CML stem cells. Encouraging reports its direction described in the related disorder acute myeloid leukemia (AML), where the antibody target CD123, CXCR4, CD44 or CD47 in AML stem cells to express anti-leukemic effects in animal AML models6-9. Furthermore, AML stem cell associated antigens CD96 and CLL-1 identified10,11, providing additional targeted candidates of this disease. Surprisingly, even in one of the most studied neoplasms of all time, called a cancer stem cell disorder, no cell surface biomarker so far recognized the CML that allows a future separation of CML stem cells in normal HSCs, when the rare CD34 + CD38 cell population12,13. Recognizing that a biomarker tool to characterize the CML stem cells, but can also be used for new treatment developments and for tracking therapeutic effects of ancient CML cells during treatment.

Our analysis of this patent is as follows:

Cantargia Ab’s patent US 9458237 B2 deals with Method for inducing cell death in acute lymphoblastic leukemic system cells.
The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in inducing cell death and / or inhibiting the growth and / or proliferation pathological cells in the stem and / or progenitor cells associated with a neoplastic hematologic disorder, in which the cells expressing IL1RAP. A related aspect the invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in identifying pathological stem cells and / or fathers cells associated with a neoplastic hematologic disorder, in which the cells expressing IL1RAP. Moreover given the medicine composition containing the agents to devise methods of using the same.

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Method and apparatus for setting or modifying programmable parameter in power driven wheelchair

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The Invacare Corporation patent solves the following problem:

Power driven wheelchair generally includes the right and left drive wheels driven by a motor controller with the corresponding right and left drive motor. A power driven wheelchair also include actuators, motors, or other acts to prevent the user support surface, such as seats, backs, feet in, feet on, or headed there. These various actuators, motors, and other devices can be controlled by a device user interface. The user interface device may include input devices, such as a joystick, pushbuttons and other types of switches, potentiometers, and other types of control devices, and output devices, such as a graphic display, alphanumeric code display, or indicators. Input devices for special user needs, such as a loss of head control, a SIP n 'puff system, a fiber optic tray battle, a closeness to head battle, or at a distance -switch war, can also be given as a device user interface or as a remote input device user interface.

Our analysis of this patent is as follows:

Invacare Corporation’s patent US 9456942 B2 deals with Method and apparatus for setting or modifying programmable parameter in power driven wheelchair.
A method and apparatus for making or modification of a standard operating automatically associated with a power driven wheelchair provided. In one embodiment, the method includes: a) operate a user interface device associated with a power driven wheelchair with a programming mode, b) selecting an automatic operating parameter associated with the operation power driven wheelchair use user interface device, c) choosing a value for the automatic standard operating use user interface devices, and d) deliver the selected value for the automatic standard operating in a part a storage device associated with power driven wheelchair use user interface device. A method and apparatus for selecting one or more automatic standard set out in a portable storage medium, and to save the selected sets to a local storage device associated with a power driven wheelchair and vice versa is also given.

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System for user interaction around a common computer game objective

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The Zynga Inc. patent solves the following problem:

In many computer games, there is a virtual world or the other thought to play a place where a player / user control the game with one or more player characters (in this attitude, player attributes, or PC ). A game engine receives inputs from the player, determine the player character, determine the outcome of events and presents the player with a display match ag what happened. In some games, there are many players, online or in a single console, where each player controls one or more player characters.

Our analysis of this patent is as follows:

Zynga Inc.’s patent US 9457278 B2 deals with System for user interaction around a common computer game objective.
A computer-implemented method comprises identifying a user to a computer-implemented game to contend with an additional user in the pursuit of a common goal game. The recognition was based at least partially on the user is not directly related, found in the relationship data, with further user. Interactions, in the computer-implemented game, among the more user and user to pursue common game goal computer-implemented game could responsive to their users.

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Method of assembling a positioning sensor and associated wiring on a medical tool

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The Mediguide Ltd. patent solves the following problem:

a. Field of Invention

Our analysis of this patent is as follows:

Mediguide Ltd.’s patent US 9457167 B2 deals with Method of assembling a positioning sensor and associated wiring on a medical tool.
An elongate medical device having an axis comprising an inner liner, a jacket radially outside the liner, a braid comprising metal embedded in the jacket, a sensor, and at least one wire electricity connected to the sensor. The at least one wire is: does the jacket and optionally disposed helically around the braids; extending longitudinally in a tube that extends generally parallel to the axis device and wherein the tube contained the jacket; and throw in a lumen, where the Lumen gave longitudinally within the jacket.

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Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity

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The Immunomedics, Inc. patent solves the following problem:

For many years it was a goal of scientists in the field of specifically targeted drug therapy using monoclonal antibodies (mAbs) for the specific delivery of toxic agents in human cancers. Conjugates of tumor-associated mAbs and suitable toxic agents developed, but have had mixed success in cancer therapy in humans, and virtually no application in other diseases, such as infectious and autoimmune diseases. The toxic agent is most often a chemotherapeutic drug, although particle-emitting radionuclides, or bacterial or plant toxins, also within the framework of mAbs, especially for cancer therapy (Sharkey and Goldenberg, CA Cancer J Clin. 2006 July-Aug.; 56 (4): 226-243) and, more recently, with radioimmunoconjugates for preclinical therapy of certain infectious diseases (Dadachova and Casadevall, QJ Nucl Med mol Imaging 2006; 50 ( 3): 193-204).

Our analysis of this patent is as follows:

Immunomedics, Inc.’s patent US 9458242 B2 deals with Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity.
The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragments. antibody can bind to the EGP-1 (TROP-2), CEACAM5, CEACAM6, CD74, CD19, CD20, CD22, CSAP, hľa-DR, or AFP MUC5ac and the immunoconjugate can be administered at a dose between 4 mg / kg and 24 mg / kg, preferably 4, 6, 8, 9, 10, 12, 16 or 18 mg / kg. When administered in specified dosages and schedules, the immunoconjugate could reduce solid tumor size, reduce or eliminate metastases and effective to treat cancer resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy.

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Abrasion resistant glove

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The Ansell Healthcare Products Llc patent solves the following problem:

Our analysis of this patent is as follows:

Ansell Healthcare Products Llc’s patent US 9456645 B2 deals with Abrasion resistant glove.
A glove comprising an elastomeric coating with a particle filler and a way to make such a glove. In particular, the glove is made of a knitted liner formed from at least one thread; an elastomeric coating that covers at least a portion of the knitted liner; and wherein the elastomeric coating comprises a filler particle having a hardness greater than the hardness of the elastomeric coating.

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Optimized cellulase enzymes

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The Sud-Chemie Ip Gmbh & Co. Kg patent solves the following problem:

The development of production processes based on renewable resources is very determined, for example for the generation of ethanol from cellulosic and lignocellulosic materials.

Our analysis of this patent is as follows:

Sud-Chemie Ip Gmbh & Co. Kg’s patent US 9458443 B2 deals with Optimized cellulase enzymes.
the invention reveals cellulase enzymes with optimized properties for processing cellulose- and lignocellulose-containing substrates. In particular, cellobiohydrolase enzyme with the attitudes expressed. The present invention provides fusion, insertion, deletion and / or substitution variants of these enzymes. Enzyme variants that increase thermostability, proteolytic stability, specific activity and / or stability in extreme pH. Nucleic acid molecules encoding said enzymes, a composition comprising said enzymes, a method for the preparation, and the use of cellulose processing and / or for the production of Biofuels expressed.

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Mucosal delivery of therapeutic molecules, proteins, or particles coupled to ceramide lipids

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The Children’s Medical Corporation patent solves the following problem:

Drug permeability and half-life are some of the limiting factors in the development of new therapeutics. This is useful to have developed ways to improve upon the drug, indicating that drug to the cells and their long half-life.

Our analysis of this patent is as follows:

Children’s Medical Corporation’s patent US 9457097 B2 deals with Mucosal delivery of therapeutic molecules, proteins, or particles coupled to ceramide lipids.
Described in these compositions and methods useful to allow for absorption (passage) of the agent of interest, such as therapeutic agents, across the epithelial and mucosal barrier and / or certain subcellular compartment of the cell, as to recycling endosome (RE), Golgi and endoplasmic reticulum (ER).

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Systems and methods for providing a user with a set of interactivity features locally on a user device

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The Dropbox, Inc. patent solves the following problem:

As applications, video applications, and other sharing applications become more popular within the device user, the service and parts are given to these applications come with inherent limitations. For example, many in the share application requires full connectivity between the server application to share content and a user device access to the server through a local application. If the level of connectivity between the server and the device is low, for example, the ability to present / give the user the inner interrupted. Furthermore, if a user device user tries to share content with a server, some sharing capability may be affected by the level of connectivity.

Our analysis of this patent is as follows:

Dropbox, Inc.’s patent US 9462054 B2 deals with Systems and methods for providing a user with a set of interactivity features locally on a user device.
Providing a user with an interactive user interface that all can join regardless of connection status will be. In some embodiments, one or more things in could choose a user of the device user and will be queued for upload to a system within the province. The matter will be organized into one or more collections in things other things kept in a users system in the administration, like the images with the same geo-temporal characteristics . A bunch of interactivity features will be available to the user to interact with the queued up things inside. This may provide the user with seamless feel as if the matter be uploaded to the system in the direction and the user can interact with the things in the system in control, even if the upload was not finished.

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