Bis-acylated hydroxylamine derivatives

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The Cardioxyl Pharmaceuticals, Inc., , The Johns Hopkins University patent solves the following problem:

Our analysis of this patent is as follows:

Cardioxyl Pharmaceuticals, Inc., , The Johns Hopkins University’s patent US 9458127 B2 deals with Bis-acylated hydroxylamine derivatives.
invention provides several bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or medicine composition for treating, preventing, or delaying the onset and / or develop a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular disease, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and the condition responsive to nitroxyl therapy.

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Methods and products to provide oral nutritional care to subjects with dementia

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The D&E; Gillespie Enterpries LLC patent solves the following problem:

Dementia is a group of disorders characterized by the loss of integrated central nervous system functions, resulting in a diminished ability to understand concepts or instructions, store and retrieve information to memory, and in behavior and personality changes.

Our analysis of this patent is as follows:

D&E; Gillespie Enterpries LLC’s patent US 9456628 B2 deals with Methods and products to provide oral nutritional care to subjects with dementia.
The present invention provides food products, nutritional programs, and procedures for meeting the nutritional needs of those with dementia and related mental disorder. In one embodiment, the invention provides a food product comprising a reversibly sealed vessel and a broth, the broth in the container and consists of a total number 200-2000 MLS, a vegetable or meat component, 300 to 2500 calories, a macronutrient caloric distribution comprising: 20-80% fat, 10-45% protein, and 10-65% carbohydrate, 2 % to about 40% medium chain triglyceride, omega 3 fatty acids in an amount of 100 to 2000 mg and less than 20 strong food particles that have a mass greater than 20 cm3. The food product, when administered to the affected subjects, positive effect (i) nutritional status; (Ii) the quality of life; (Iii) disease course; (B) the need for help from a care giver; (Vi) subject carrying out a nutritional plan to use in food products, and (viii) ease of monitoring compliance with caretaker for verification.

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Ball sensing

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The Wilson Sporting Goods Co. patent solves the following problem:

Baseball is known as America's pastime, and growing in popularity worldwide. Thousands of children and adults enjoy playing baseball or softball. Pitching in baseball or softball is a critical part of the game. Pitching is a skill that pitchers to learn and develop in overtime in hours, weeks, months and years in practice. The practice is often complex and not enough feedback to facilitate optimal pitching skills improvement.

Our analysis of this patent is as follows:

Wilson Sporting Goods Co.’s patent US 9457251 B2 deals with Ball sensing.
A method including the steps of receiving a signal indicating movement in a physical ball relative to a strike zone during a pitch, get some batting form of a simulated batter equivalent to the identified event physical ball relative to the strike zone during the pitch, and display of a computing device in simulated result pitch for pitch base got batting form of simulated batter for the event showed.

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Bone plates, screws and instruments

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The Osteomed, Llc patent solves the following problem:

The present disclosure relates to bone plates, screws and other fasteners, and related instruments. included in the sample with a screw and washer systems with instruments, polyaxial screw and plate systems, bone clamp system with spacers, sleeves, and / or cages, multi-level bone clamp systems, minimally invasive bone clamp systems, motion preservation systems and instruments for handling plates, applying compression, and applying locking forces. More particularly, the present disclosure placed in the context of spinal surgery, such as spine fusion or motion preservation.

Our analysis of this patent is as follows:

Osteomed, Llc’s patent US 9456858 B2 deals with Bone plates, screws and instruments.
Systems for trauma and / or joint fusion implants and instruments included transarticular screw and intra-articular washer, polyaxial screw and plate, and multi-level polyaxial bone clamps, and minimally invasive adaptations.

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Method for treating a CX3CR1-associated disease with CX3CR1-binding polypeptides

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The Boehringer Ingelheim International Gmbh patent solves the following problem:

CX3CR1 is a G-protein coupled integral membrane proteins, which is a chemokine receptor. It is usually expressed in cells such as monocytes, dendritic cells and T cells associated with the initiation and progression of atherosclerotic plaque. It is upregulated in monocyte oxidized lipid and mediates migration of these cells to live within the plaques. The unique ligand fractalkine (FKN) expressed on the surface of vascular endothelial and smooth muscle cells in the wound where it modulates leukocyte adhesion. Fractalkine also released into circulation the proteolytic cleavage where it acts as a chemotactic agent.

Our analysis of this patent is as follows:

Boehringer Ingelheim International Gmbh’s patent US 9458235 B2 deals with Method for treating a CX3CR1-associated disease with CX3CR1-binding polypeptides.
The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acid encoding such polypeptides; to methods of preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and the use of such polypeptides or the composition, in particular for prophylactic, therapeutic and diagnostic purposes.

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Method for treating a neurological disorder associated with hypoxia using a small moleucule MIF inhibitor

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The The Feinstein Institute For Medical Research patent solves the following problem:

Throughout this application various publications aimed at a number or name in parentheses. The disclosure of these publications, as well as all patents, patent applications and publications books cited here, which included a discussion of their overall application subject to more fully describe the art of the subject invention pertains .

Our analysis of this patent is as follows:

The Feinstein Institute For Medical Research’s patent US 9457013 B2 deals with Method for treating a neurological disorder associated with hypoxia using a small moleucule MIF inhibitor.
Procedures are given to treat pathologies associated with hypoxia with a MIF inhibitor. Procedures are given for the treatment of a subject with, or at risk for pulmonary hypertension, with a MIF inhibitor. Methods also provided for reating a subject with, or at risk from, a CNS disorder associated with hypoxia, with a MIF inhibitor. Gave way to treat severe chronic lung disease, hypoxia-induced right ventricular hypertrophy or hypoxia-induced pulmonary vascular remodeling with a MIF inhibitor. Methods of diagnosis of a subject with pulmonary hypertension also given.

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Methods and apparatuses for printing three dimensional images

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The Virginia Venture Industries, Llc patent solves the following problem:

This invention relates to various methods and apparatuses for printing three-dimensional objects in three-dimensional printers use three-dimensional math / number of three-dimensional objects .

Our analysis of this patent is as follows:

Virginia Venture Industries, Llc’s patent US 9457519 B2 deals with Methods and apparatuses for printing three dimensional images.
System and method for printing a 3D object in a three-dimensional (3D) printer described. The way semi-automatic or automatic describe something in a picture, receive a 3D model that matches said things said 3D model, and send the matched 3D model in a 3D tig -imprinta.

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Highly concentrated aqueous protein solution with reduced viscosity

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The Adocia patent solves the following problem:

Our analysis of this patent is as follows:

Adocia’s patent US 9457089 B2 deals with Highly concentrated aqueous protein solution with reduced viscosity.
In an aqueous solution, a composition includes at least one protein, including at least one antibody fragments, and at least one water-soluble viscosity-reducing agent selected from the group consisting of cytidine, 2-deoxycytidine, uridine, 2-deoxyuridine, thymidine and ribothymidine, alone or as a mixture. proteins include at least one antibody fragment in a concentration greater than or equal to 50 mg / ml.

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Method for determining whether a point lies along a curve in a multidimensional space

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The Yandex Europe Ag patent solves the following problem:

In many applications in the computer, the data can be represented by a curve through the two or more levels of a multi-dimensional space, the second data may represent a point in the same multi dimensional space, and it is useful to determine the points represent the second data lies along the curve representative of the first data. For example, the first data to be represented in some way in all the land in a geographic region, and the second data that represents an estimated position of a vehicle within the geographic region, may be obtained from a global positioning system (GPS) satellite. In such cases, it may be useful to determine if the vehicle were on the way, for example to evaluate whether the driver of the car should be told either to continue in some way or correction way.

Our analysis of this patent is as follows:

Yandex Europe Ag’s patent US 9459095 B2 deals with Method for determining whether a point lies along a curve in a multidimensional space.
There is disclosed a computer-implemented method for determining whether a point lies along a curve in a multi-dimensional space and program instructions executable to perform procedures. The methods include the value of the first curve coordinates defining each one in a position and a form of the first curve in multi-dimensional space; recognition of the regional multi-dimensional space each containing a respective portion of the first curve while creating a second curve once the first curve; and storing, in a non-transitory computer-readable medium, region coordinates at least one of the region; where an analysis of the region coordinates and point coordinates defining a position of point to multi-dimensional space is executable to provide a user with an indication of the points lie along the first curve or an indication that the point does not lie along the first curve. The other implementing comprising performing said analysis and said give signs.

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Mucosal delivery of therapeutic molecules, proteins, or particles coupled to ceramide lipids

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The Children’s Medical Corporation patent solves the following problem:

Drug permeability and half-life are some of the limiting factors in the development of new therapeutics. This is useful to have developed ways to improve upon the drug, indicating that drug to the cells and their long half-life.

Our analysis of this patent is as follows:

Children’s Medical Corporation’s patent US 9457097 B2 deals with Mucosal delivery of therapeutic molecules, proteins, or particles coupled to ceramide lipids.
Described in these compositions and methods useful to allow for absorption (passage) of the agent of interest, such as therapeutic agents, across the epithelial and mucosal barrier and / or certain subcellular compartment of the cell, as to recycling endosome (RE), Golgi and endoplasmic reticulum (ER).

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