Compositions and methods for osteogenic gene therapy

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The Loma Linda University, , The United States Of America As Represented By The Department Of Veteran Affairs patent solves the following problem:

Growth factors, including the members of the FGF and Wnt family, pleiotropic regulators of growth, inequality, migration, and live in a variety of cell types. For example, the basic fibroblast growth factor (bFGF or FGF-2) is used to influence cellular growth, inequality and migration (Bikfalvi et al, Endocrine Rev. 18 :. 26-45, 1997; Friesel et al, FASEB J. 9: 919-925, 1995; Moyamoto et al, J. Cell Physiol 177: 58-67, 1998; D'Amore et al, growth factors 8: 61-75, 1993) and is also a potent stimulator. in angiogenesis (Moyamoto et al, J. Cell Physiol 177: …. 58-67, 1998; D'Amore et al, growth factors 8: 61-75, 1993) and in hematopoiesis in vivo (Allouche et al, program.. Growth Factor 6: 35-48, 1995). FGF-2 is involved in organogenesis (Martin, Gene Dev 12 :. 1571-1586, 1998), vascularization (. D'Amore et al, growth factors 8: 61-75, 1993), and wound healing ( Ortega et al., Proc Natl Acad Sci USA, 95: … 5672-5677, 1998), and plays an important role in the discrepancy and / or the function of various organs, including the nervous system (Ortega et al, Proc Natl Acad Sci USA 95: 5672-5677, 1998), the skeleton (Montero et al, J. Clin invest 105: 1085-1093, 2000 ), and some other organs (Bikfalvi et al, endocrine Rev.. 18: 26-45, 1997). Because of angiogenic and anabolic properties, FGF-2 has received much attention for potential clinical applications, including wound healing and tissue repair.

Our analysis of this patent is as follows:

Loma Linda University, , The United States Of America As Represented By The Department Of Veteran Affairs’s patent US 9458215 B2 deals with Compositions and methods for osteogenic gene therapy.
The present disclosure provides compositions and methods for increasing bone growth and / or enhancing wound healing, for example, the fracture to heal. disclosure provides artificial nucleic acid is useful for promoting bone growth. For example, the disclosure provides an artificial nucleic acid encoding a fibroblast growth factor-2 (FGF-2) Analog. disclosure also provides vectors and cells using these nucleic acid, as well as FGF-2 analogs encode them. exposure gave the mice a system of bone marrow transplantation and procedures for bringing in as well as methods for the use of the system. Methods force for division and / or force the division to a hematopoietic stem cells also given, as a means for promoting bone growth and / or wound healing (for example, to fracture ayo).

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Integrated insulin delivery system with continuous glucose sensor

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The Dexcom, Inc. patent solves the following problem:

Diabetes mellitus is a disease of the pancreas does not make enough insulin (Type I or insulin dependent) and / or the insulin is not effective (Type 2 or non-insulin dependent). In diabetic condition, the victim suffers from high glucose, which can cause an array of physiological derangements (for example, kidney failure, skin ulcers, or bleeding in the vitreous of the eye) associated with the deterioration of the small blood vessels. A hypoglycemic reaction (low glucose) may be challenged by an accidental overdose of insulin, or after a normal dose of insulin or glucose-lowering agent with extraordinary exercise or insufficient food.

Our analysis of this patent is as follows:

Dexcom, Inc.’s patent US 9457146 B2 deals with Integrated insulin delivery system with continuous glucose sensor.
Systems and methods for combining a continuous glucose sensor 12, including a receiver 14, a medication delivery device 16, a controller module, and optionally a point glucose monitor 18 given. Integration can be manual, semi-automated and / or fully automated.

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Method for treating a neurological disorder associated with hypoxia using a small moleucule MIF inhibitor

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The The Feinstein Institute For Medical Research patent solves the following problem:

Throughout this application various publications aimed at a number or name in parentheses. The disclosure of these publications, as well as all patents, patent applications and publications books cited here, which included a discussion of their overall application subject to more fully describe the art of the subject invention pertains .

Our analysis of this patent is as follows:

The Feinstein Institute For Medical Research’s patent US 9457013 B2 deals with Method for treating a neurological disorder associated with hypoxia using a small moleucule MIF inhibitor.
Procedures are given to treat pathologies associated with hypoxia with a MIF inhibitor. Procedures are given for the treatment of a subject with, or at risk for pulmonary hypertension, with a MIF inhibitor. Methods also provided for reating a subject with, or at risk from, a CNS disorder associated with hypoxia, with a MIF inhibitor. Gave way to treat severe chronic lung disease, hypoxia-induced right ventricular hypertrophy or hypoxia-induced pulmonary vascular remodeling with a MIF inhibitor. Methods of diagnosis of a subject with pulmonary hypertension also given.

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Airport baggage handling system

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The Vanderlande Industries, B.V. patent solves the following problem:

Baggage handling system for the transfer of baggage from passenger check-in station in plane loading zones facilitate placement of the luggage on the plane are well known. Often, airport baggage handling system includes screening practices to examine luggage contraband, for example, explosives, drugs, weapons, etc. In some baggage handling systems, baggage manually fed through a screening device and, after, the hand placed into a conveyor to the luggage handling system. In some baggage handling system, the screening device given in-line baggage handling system.

Our analysis of this patent is as follows:

Vanderlande Industries, B.V.’s patent US 9457917 B2 deals with Airport baggage handling system.
An airport baggage handling system described in the baggage transfer between the airport stations airline passenger and loading zones. The airport baggage handling system includes in-line screening devices including at least a high resolution or high risk screening device and at least one low resolution or low risk screening device. Each piece of checked baggage given a tag including, inter alia, information about the security situation in the piece of luggage. A computer control system for controlling operation of the baggage handling system that uses information about the security situation in the piece of luggage to selectively route the piece of luggage from one of the high and low risk devices scanning. In some pictures, the security situation in the luggage taken from the security status of passengers with luggage.

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Exercise apparatus

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The Cybex International, Inc. patent solves the following problem:

Exercise machine for simulating walking or running is known and used for managing the movement of the feet of a user and feet in a kind of repeated paths of travel. The user often made in an exercise to use as a walking or running machine for an extended period of time as one to 30 minutes without interruption, and do not change to another -again exercise using a different machine as a user can do in a circuit exercise protocol. The machines typically include an electrically powered mechanism that user can activate to adjust certain aspects of the machine like the kind of opposition. Running or walking machine simulation often refers to elliptical path machine designed to turn the foot pedal foot the user was directed to the pedal and the feet of the user to travel in an elliptical or arcuate path. The type of resistance exercise performance in such a machine often varies linearly with the degree of force or speed by the user into a moving mechanical parts of the equipment. The way to drive foot pedal the machine will not be regulated other than to change the shape of the ellipse. The feet travel along a different path from the back to the front than from front to back on the elliptical machine.

Our analysis of this patent is as follows:

Cybex International, Inc.’s patent US 9457230 B2 deals with Exercise apparatus.
An exercise apparatus comprising: a foot support, a user interface which includes a visual display, the feet support user movable frame back and through any one of a a plurality of complete, reproducible and different arc of a master arcuate path, the foot support connected to a selection device that enables the user to choose any one of the plurality of arch part, one or more detectors adapted to detect one or more of the force, energy or power user made up during the foot support or distance or velocity to travel on foot or support against society during the course of performance the user of all or a part of an exercise cycle, the visual display to display a visually recognizable format to one or more of the force, strength, power, distance -on, time or velocity.

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Thermo-mechanically controlled implants and methods of use

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The J.W. Medical Systems Ltd. patent solves the following problem:

This creation account in general medical equipment and procedures, and especially to implants and biodegradable implants for use in the vascular system as well as other body lumens and cavities.

Our analysis of this patent is as follows:

J.W. Medical Systems Ltd.’s patent US 9457133 B2 deals with Thermo-mechanically controlled implants and methods of use.
An implant consists of a framework that can be placed on the tissue and having a first material property at normal body temperature. The first material possessions are variable in temperature above normal body temperature. implant also has a plurality of particles dispersed in the structure adapted to convert incident radiation into heat energy when irradiated with electromagnetic radiation. The particles are in thermal contact with the structure so that exposure to particles of incident radiation raises the temperature in the building so again in the first material properties relative to the first material property at normal temperature body.

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Detection method of life activity, measuring device of life activity, transmission method of life activity detection signal, or service based on life activity information

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The Hideo Ando patent solves the following problem:

The present invention relates to a method of measuring a control method for measuring (in vivo measurements) or control, in a living state, dynamic activities of life unchangeable also high speed in a life that things like a beast with a man or a plant or change it in a non-contact and noninvasive procedures.

Our analysis of this patent is as follows:

Hideo Ando’s patent US 9456776 B2 deals with Detection method of life activity, measuring device of life activity, transmission method of life activity detection signal, or service based on life activity information.
According to a method of measuring or control a lifestyle activity, a life that is illuminated with an electromagnetic wave with a wavelength of a designated waveband, and a character in a local area of ​​life that notice, or a life of its activity controlled. The appointed waveband base describes the phenomena used to identify or control an activity of living things, or a change in state. This local area is a place that consists of one or more cells.

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Antibody reacting with native Cochlin-tomoprotein (CTP) and method for measuring CTP using same

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The Saitama Medical University patent solves the following problem:

Cochlin tomoprotein (called referred to as CTP), which is a 16 kDa isoform Cochlin in perilymph, is a promising diagnostic marker for perilymph fistula because it is not found in other body fluids to be now in the middle ear such as cerebrospinal fluid, blood and saliva (Patent Literature 1, literature nonpatent 1-5). Perilymph fistula is a disease of the inner ear dysfunction so when labyrinthine windows separate the inner ear from the middle ear ruptured, and perilymph of the inner ear filled with leaks to the middle ears. Because the symptoms can be ameliorated by the end of the labyrinthine windows in the early stages when, early diagnosis is very important.

Our analysis of this patent is as follows:

Saitama Medical University’s patent US 9458210 B2 deals with Antibody reacting with native Cochlin-tomoprotein (CTP) and method for measuring CTP using same.
An immunological measurements made using the anti-CTP antibody characterized by the recognition of an antigenic determinant include the polypeptide represented by amino acid numbers 118-132 of SEQ ID NO: 1, and respond to indigenous Cochlin -tomoprotein (CTP).

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Systems and methods for providing a user with a set of interactivity features locally on a user device

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The Dropbox, Inc. patent solves the following problem:

As applications, video applications, and other sharing applications become more popular within the device user, the service and parts are given to these applications come with inherent limitations. For example, many in the share application requires full connectivity between the server application to share content and a user device access to the server through a local application. If the level of connectivity between the server and the device is low, for example, the ability to present / give the user the inner interrupted. Furthermore, if a user device user tries to share content with a server, some sharing capability may be affected by the level of connectivity.

Our analysis of this patent is as follows:

Dropbox, Inc.’s patent US 9462054 B2 deals with Systems and methods for providing a user with a set of interactivity features locally on a user device.
Providing a user with an interactive user interface that all can join regardless of connection status will be. In some embodiments, one or more things in could choose a user of the device user and will be queued for upload to a system within the province. The matter will be organized into one or more collections in things other things kept in a users system in the administration, like the images with the same geo-temporal characteristics . A bunch of interactivity features will be available to the user to interact with the queued up things inside. This may provide the user with seamless feel as if the matter be uploaded to the system in the direction and the user can interact with the things in the system in control, even if the upload was not finished.

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Filter element and filter system with a filter element

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The Mann+Hummel Gmbh patent solves the following problem:

the invention of a filter element, in particular for use as an air filter in an internal combustion engine, as well as a filter system for the installation of such a filter element.

Our analysis of this patent is as follows:

Mann+Hummel Gmbh’s patent US 9457308 B2 deals with Filter element and filter system with a filter element.
A filter element having a filter body having a longitudinal axis, wherein the filter body has a first end with a first end face and a second end to a second end face opposite the first end in the direction of the longitudinal axis. The filter body provided inside and outside circumferential surfaces permeable for a medium filtered. A first end disk arranged on the first end face and a second end disk arranged on the second end face. The outer circumferential surface of the filter body has at least one fluid-tight is the place to be for the medium filtered. The fluid-tight place is a future flow protector or an improper management defender resting on the outer circumferential surface.

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