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The Loma Linda University, , The United States Of America As Represented By The Department Of Veteran Affairs patent solves the following problem:
Growth factors, including the members of the FGF and Wnt family, pleiotropic regulators of growth, inequality, migration, and live in a variety of cell types. For example, the basic fibroblast growth factor (bFGF or FGF-2) is used to influence cellular growth, inequality and migration (Bikfalvi et al, Endocrine Rev. 18 :. 26-45, 1997; Friesel et al, FASEB J. 9: 919-925, 1995; Moyamoto et al, J. Cell Physiol 177: 58-67, 1998; D'Amore et al, growth factors 8: 61-75, 1993) and is also a potent stimulator. in angiogenesis (Moyamoto et al, J. Cell Physiol 177: …. 58-67, 1998; D'Amore et al, growth factors 8: 61-75, 1993) and in hematopoiesis in vivo (Allouche et al, program.. Growth Factor 6: 35-48, 1995). FGF-2 is involved in organogenesis (Martin, Gene Dev 12 :. 1571-1586, 1998), vascularization (. D'Amore et al, growth factors 8: 61-75, 1993), and wound healing ( Ortega et al., Proc Natl Acad Sci USA, 95: … 5672-5677, 1998), and plays an important role in the discrepancy and / or the function of various organs, including the nervous system (Ortega et al, Proc Natl Acad Sci USA 95: 5672-5677, 1998), the skeleton (Montero et al, J. Clin invest 105: 1085-1093, 2000 ), and some other organs (Bikfalvi et al, endocrine Rev.. 18: 26-45, 1997). Because of angiogenic and anabolic properties, FGF-2 has received much attention for potential clinical applications, including wound healing and tissue repair.
Our analysis of this patent is as follows:
Loma Linda University, , The United States Of America As Represented By The Department Of Veteran Affairs’s patent US 9458215 B2 deals with Compositions and methods for osteogenic gene therapy.
The present disclosure provides compositions and methods for increasing bone growth and / or enhancing wound healing, for example, the fracture to heal. disclosure provides artificial nucleic acid is useful for promoting bone growth. For example, the disclosure provides an artificial nucleic acid encoding a fibroblast growth factor-2 (FGF-2) Analog. disclosure also provides vectors and cells using these nucleic acid, as well as FGF-2 analogs encode them. exposure gave the mice a system of bone marrow transplantation and procedures for bringing in as well as methods for the use of the system. Methods force for division and / or force the division to a hematopoietic stem cells also given, as a means for promoting bone growth and / or wound healing (for example, to fracture ayo).
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