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The Tripep Ab patent solves the following problem:
The delivery of therapeutic materials, such as genetic material, to tissue that has a wide range of useful applications including vaccination, replacement of a defective gene, DNA immunization, introduction of an immunogen, anti-sense therapy, and miRNA, RNAi, aptamer, or siRNA therapy. For example, nucleic acid, such as DNA, for example, can be injected into the tissue, where the nucleic acid derived from the surrounding cells inefficiently. DNA introduced in this way a protein encoding DNA. The successful delivery of nucleic acid into the tissue and the uptake of nucleic acid into cells is difficult, especially when a significant amount of protein expression was determined (for example, as desired for DNA-based vaccination ). Conventional injection of genetic material into tissues in general result in poor uptake in cells and low levels of protein expression, if any at all.
Our analysis of this patent is as follows:
Tripep Ab’s patent US 9457183 B2 deals with Injection needle and device.
Some needle assemblies and intracellular delivery devices used for delivery of prophylactic and / or therapeutic material (ie, given agent) into a tissue of a subject expressed. At best, the needle assemblies and / or intracellular delivery device comprises a needle and / or needle electrodes, disposed in a forest (for example, a Y-type war with three outer needle with a center the needle), where each needle in the forest is a closed end and a plurality of apertures along each needle barrel, and the apertures of the needle gun out war needle position to deliver delivered agents into the apertures in the center pin and / or a neighboring needle, but not without the active zone defined area within the cloud forest and the apertures in the needle barrel in center needle position to deliver vicarious agents toward the outer needle.
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