Robotic catheter system and methods

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The Hansen Medical, Inc. patent solves the following problem:

Robotic interventional systems and devices that are well suited for use to perform minimally invasive medical procedures, contrary to conventional techniques in which the patient's body cavity open to allow access to the surgeon's hand in internal organs. For example, there is a need for a highly controllable minimally sized systems to perform imaging, diagnosis, and treatment of tissues that lie deep within a patient, and can be obtained by naturally-occurring way as blood vessels or other lumens, with operation wounds did minimized size, or both.

Our analysis of this patent is as follows:

Hansen Medical, Inc.’s patent US 9457168 B2 deals with Robotic catheter system and methods.
The equipment in an image of the present invention comprises a flexible sheath instrument, a flexible guiding instrument, and an instrument. The flexible sheath instrument comprising a first instrument base removably coupleable to an instrument driver and describes a sheath instrument working Lumen. The flexible guiding instrument comprising a second base instrument removably coupleable instrument driver and threaded through the sheath instrument working Lumen. The guide also describes the instrument a guiding instrument working Lumen. The tool is threaded through the guiding instrument working Lumen. For these facilities, the guiding sheath instruments and instruments independently controllable relative to one another.

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Flagellin related polypeptides and uses thereof

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The Cleveland Clinic Foundation patent solves the following problem:

The progression from normal cells to tumor cells involves a loss of negative mechanisms of growth regulation, including resistance to growth inhibitory stimuli and a lack of confidence in growth factors and hormones. Traditional cancer treatments based on radiation or cytotoxic drugs rely on the differences in growth control in normal and malignant cells. Traditional cancer treatments subject cells to severe genotoxic stress. Under these circumstances, the majority of normal cells become arrested and therefore saved, while tumor cells continue to divide and die.

Our analysis of this patent is as follows:

Cleveland Clinic Foundation’s patent US 9457061 B2 deals with Flagellin related polypeptides and uses thereof.
The use of flagellin and flagellin related polypeptides to protect the mammal from the effects of apoptosis described.

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Pharmaceutical compositions providing enhanced drug concentrations

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The Bend Research, Inc. patent solves the following problem:

The invention relates to compositions comprising a combination of a drug and a concentration-enhancing polymer that enhances the concentration of the drug in a use environment relative to control compositions from the concentration-enhancing polymer .

Our analysis of this patent is as follows:

Bend Research, Inc.’s patent US 9457095 B2 deals with Pharmaceutical compositions providing enhanced drug concentrations.
A drug in a solubility-improved form with a concentration-enhancing polymer in a sufficient amount such that the combination provides substantially enhanced drug concentration in a use environment relative to a control consisting of same amount in the same solubility-improved form of the drug without the concentration-enhancing polymer.

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Exercise apparatus

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The Cybex International, Inc. patent solves the following problem:

Exercise machine for simulating walking or running is known and used for managing the movement of the feet of a user and feet in a kind of repeated paths of travel. The user often made in an exercise to use as a walking or running machine for an extended period of time as one to 30 minutes without interruption, and do not change to another -again exercise using a different machine as a user can do in a circuit exercise protocol. The machines typically include an electrically powered mechanism that user can activate to adjust certain aspects of the machine like the kind of opposition. Running or walking machine simulation often refers to elliptical path machine designed to turn the foot pedal foot the user was directed to the pedal and the feet of the user to travel in an elliptical or arcuate path. The type of resistance exercise performance in such a machine often varies linearly with the degree of force or speed by the user into a moving mechanical parts of the equipment. The way to drive foot pedal the machine will not be regulated other than to change the shape of the ellipse. The feet travel along a different path from the back to the front than from front to back on the elliptical machine.

Our analysis of this patent is as follows:

Cybex International, Inc.’s patent US 9457230 B2 deals with Exercise apparatus.
An exercise apparatus comprising: a foot support, a user interface which includes a visual display, the feet support user movable frame back and through any one of a a plurality of complete, reproducible and different arc of a master arcuate path, the foot support connected to a selection device that enables the user to choose any one of the plurality of arch part, one or more detectors adapted to detect one or more of the force, energy or power user made up during the foot support or distance or velocity to travel on foot or support against society during the course of performance the user of all or a part of an exercise cycle, the visual display to display a visually recognizable format to one or more of the force, strength, power, distance -on, time or velocity.

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Hydrogels for delivery of therapeutic polypeptides

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The The Board Of Trustees Of The University Of Illinois patent solves the following problem:

Target and local delivery of drugs is a goal of medical and pharmaceutical industries. Target drug delivery aims to optimize drug effective by local therapeutic effect to the sick or infected site or organ of action. A successful therapeutic target provides a significant reduction in drug toxicity, reducing the dose of drug, and increased treatment efficacy as compared to, for example, therapeutics that can specifically target a diseased tissue or organ. Decreased bioavailability of drugs is often a result of their non-specific nature. Furthermore, drug efficacy depends upon the ability of the drug to reach its target in sufficient quantity to maintain therapeutic levels for the desired period of time. Therefore, there is a need for new compositions and methods of local and targeted delivery of therapeutics that is not subject to the same physiological barriers often experienced by, for example, drugs efficaciously not give their therapeutic effects in some target target.

Our analysis of this patent is as follows:

The Board Of Trustees Of The University Of Illinois’s patent US 9457101 B2 deals with Hydrogels for delivery of therapeutic polypeptides.
Expressed here is a hydrogel composition comprising a polymer covalently linked to Glutathione (GSH). also disclosed herein is a method of providing local delivery of one or more agents to a subject suffering from a disease. method comprising administering to the subject a GST / GSH affinity hydrogel containing a therapeutically effective amount of one or more agents.

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Method and system for identifying vehicle collisions using sensor data

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The State Farm Mutual Automobile Insurance Company patent solves the following problem:

Now, vehicle collisions can be identified by the driver, passengers and witnesses who saw or was involved in the collision. However, such collisions are not recognized and reported in real-time, for the driver, passengers and witnesses involved in the collision will be capacity or unwilling to report the collision. In addition, an assessment of a vehicle collision can be performed after the collision occurs, and may be based on reports of vehicle damage and / or reports to the police.

Our analysis of this patent is as follows:

State Farm Mutual Automobile Insurance Company’s patent US 9457754 B1 deals with Method and system for identifying vehicle collisions using sensor data.
A method and system for identifying car collisions in real-time or at least near real-time based on statistical data collected from the previous car collisions. portable computing device to a user obtains sensor data from the sensor to the portable computing device and compare the sensor data into a statistical model indicates a vehicle collision. As indicated in portable computing device in a vehicle collision based on comparison, notifications can be sent to emergency contacts and / or emergency personnel to provide assistance to the user.

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Dental chair

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The Sargon Lazarof patent solves the following problem:

This creation is related to the field of Dentistry. More particularly this invention relates to the field of dental chair.

Our analysis of this patent is as follows:

Sargon Lazarof’s patent US 9456948 B1 deals with Dental chair.
A dental chair and given a seat assembly comprising a backrest, a seat, and a base; and at least one set of dock utility thrown in a chair, next to the seat, each port has a quick release due to receive a flexible conduit connected to a hand piece.

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Powered ambulance cot with an automated cot control system

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The Ferno-Washington, Inc. patent solves the following problem:

There is a kind of emergency patients delivered in use today. The emergency patient transporting can be designed to carry and load Bariatric patients into an ambulance. For example, the PROFlexX bed, by Ferno-Washington, Inc. Wilmington, Ohio USA, is one of those vehicles that are patient as a hand operated cots that provide strength and support for loads of 700 pounds (317,5 kg) . PROFlexX bed includes a patient support portion attached to a wheel undercarriage. The wheels under carriage includes an X-frame geometry to be transitioned between nine selectable positions. A recognized advantage of such a bed design is that the X-frame provides minimal flex and a low center of gravity for all of the selectable positions. Another recognized the advantage of such a bed design is the selectable position to provide better leverage manually lifting and loading Bariatric patients.

Our analysis of this patent is as follows:

Ferno-Washington, Inc.’s patent US 9456938 B2 deals with Powered ambulance cot with an automated cot control system.
A powered ambulance cot and upbringing and humble bed as well as loading and unloading the bed made. bed includes a support frame and legs, each leg with a wheel. An actuator with an actuation system to connect the frame and legs, and configured to effect changes in the length of the frame relative to the wheel of each of the legs. A control system controls activation of the actuation system, and detects the actuator at a first location relative to the frame, where the first location remote from a second place and a hard end actuator remote from each wheel closer to the frame, and a presence of a signal requesting a change in the length of said support frame so causes the foot to move relative to the frame support.

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Nucleic acid molecules encoding antibodies which bind CCR4 and uses thereof

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The Cancer Research Technology Limited patent solves the following problem:

With more than 800 members, G-protein-coupled receptor (GPCRs) represent the largest family of cell surface molecules involved in signal transmission, accounting for 2% of the total gene encoded human genome. The members of the GPCR share a common membrane Topology: an extracellular N-terminus, an intracellular C-terminus and seven transmembrane (TM) helices connected by three intracellular loops and three extracellular loops. On the basis of their shared topological structure, GPCRs are also referred to as seven transmembrane (7tm) receptor. These receptors control key physiological functions, including neurotransmission, hormone and enzyme release from endocrine and exocrine glands, immune responses, cardiac- and smooth-muscle and blood pressure regulation. Their dysfunction contributes to some of the most widespread human diseases. Emerging experimental and clinical data showed that GPCRs have an important role in cancer growth and metastasis. Therefore, the possibility exists that some GPCRs could be target for anti-cancer drugs.

Our analysis of this patent is as follows:

Cancer Research Technology Limited’s patent US 9458238 B2 deals with Nucleic acid molecules encoding antibodies which bind CCR4 and uses thereof.
The present invention provides antibodies that bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and that is capable of inhibiting the binding of macrophage-derived chemokine (MDC) and / or thymus and activation regulated chemokine (TARC) CCR4. Also provides inter alia immunoconjugates and compositions comprising these antibodies and methods and uses involving the same antibody, particularly in the medical and diagnostic fields.

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Dock-and-lock (DNL) vaccines for cancer therapy

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The Ibc Pharmaceuticals, Inc. patent solves the following problem:

The present invention relates to the design and generation of dendritic cell-based, in vivo vaccine target for cancer therapy, such as multiple myeloma antigen. In preferred embodiments of the vaccine produced by the dock-and-lock (DNL) method, the effector moieties attached to anchor domain (AD) obtained from the AKAP protein dimerization and docking domain (DDD) moieties obtained of protein kinase a (PKA). DNL complexes generated when DDD moieties spontaneously dimerize and bind to an AD moiety, resulting in a complex with a 2: 1 stoichiometry between DDD and AD-related effectors. In more preferred embodiments, the effector moieties comprise a humanized anti-CD74 antibody, and a tumor-associated xenoantigen, such as a CD20 xenoantigen. In most preferred embodiments, the anti-CD74 antibody is an antibody hLL1. The DNL constructs for use in preparing pharmaceutical compositions, for the generation of vaccines against cancer, multiple myeloma (MM), and for the induction of an immune response against the tumor antigen expression cells, such as CD20 positive cancer cells in patients with multiple myeloma or other CD20-expressing cancers.

Our analysis of this patent is as follows:

Ibc Pharmaceuticals, Inc.’s patent US 9457072 B2 deals with Dock-and-lock (DNL) vaccines for cancer therapy.
The present invention concerns methods and compositions for the construction of the anti-cancer vaccine DNL complexes using dock-and-lock technology. In preferred embodiments, the anti-cancer vaccine DNL complex comprising an antibody moiety that binds to dendritic cells, like an anti-CD74 antibody or antigen-binding fragment thereof, is included in an AD (anchor domain) moiety and a xenoantigen, such as CD20, attached to a DDD (dimerization and docking domain) moiety, where two copies of DDD moiety form a dimer that binds AD moiety, resulting in the formation of the DNL complicated. The anti-cancer vaccine DNL complex is able to induce an immune response against xenoantigen expressing cancer cells, as CD138negCD20 + MM stem cells and inducing apoptosis and inhibiting the growth of or eliminate cancer cells.

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