Compositions and methods for osteogenic gene therapy

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The Loma Linda University, , The United States Of America As Represented By The Department Of Veteran Affairs patent solves the following problem:

Growth factors, including the members of the FGF and Wnt family, pleiotropic regulators of growth, inequality, migration, and live in a variety of cell types. For example, the basic fibroblast growth factor (bFGF or FGF-2) is used to influence cellular growth, inequality and migration (Bikfalvi et al, Endocrine Rev. 18 :. 26-45, 1997; Friesel et al, FASEB J. 9: 919-925, 1995; Moyamoto et al, J. Cell Physiol 177: 58-67, 1998; D'Amore et al, growth factors 8: 61-75, 1993) and is also a potent stimulator. in angiogenesis (Moyamoto et al, J. Cell Physiol 177: …. 58-67, 1998; D'Amore et al, growth factors 8: 61-75, 1993) and in hematopoiesis in vivo (Allouche et al, program.. Growth Factor 6: 35-48, 1995). FGF-2 is involved in organogenesis (Martin, Gene Dev 12 :. 1571-1586, 1998), vascularization (. D'Amore et al, growth factors 8: 61-75, 1993), and wound healing ( Ortega et al., Proc Natl Acad Sci USA, 95: … 5672-5677, 1998), and plays an important role in the discrepancy and / or the function of various organs, including the nervous system (Ortega et al, Proc Natl Acad Sci USA 95: 5672-5677, 1998), the skeleton (Montero et al, J. Clin invest 105: 1085-1093, 2000 ), and some other organs (Bikfalvi et al, endocrine Rev.. 18: 26-45, 1997). Because of angiogenic and anabolic properties, FGF-2 has received much attention for potential clinical applications, including wound healing and tissue repair.

Our analysis of this patent is as follows:

Loma Linda University, , The United States Of America As Represented By The Department Of Veteran Affairs’s patent US 9458215 B2 deals with Compositions and methods for osteogenic gene therapy.
The present disclosure provides compositions and methods for increasing bone growth and / or enhancing wound healing, for example, the fracture to heal. disclosure provides artificial nucleic acid is useful for promoting bone growth. For example, the disclosure provides an artificial nucleic acid encoding a fibroblast growth factor-2 (FGF-2) Analog. disclosure also provides vectors and cells using these nucleic acid, as well as FGF-2 analogs encode them. exposure gave the mice a system of bone marrow transplantation and procedures for bringing in as well as methods for the use of the system. Methods force for division and / or force the division to a hematopoietic stem cells also given, as a means for promoting bone growth and / or wound healing (for example, to fracture ayo).

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System, method, and computer program product for input/output buffer modeling

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The Cadence Design Systems, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Cadence Design Systems, Inc.’s patent US 9460250 B1 deals with System, method, and computer program product for input/output buffer modeling.
The present disclosure relates to a computer-implemented method for transient simulation of an input / output buffer models. methods may include the creation of an input / output buffer data file associated with a first model of an electrical circuit. method may also include determining at least one of a node voltage and a current branches associated with the electrical circuit in use, at least in part, a way latency insertion, the method may further include performing one or more simulations at a second model of an electrical circuit, one or more superstitious use, at least in part, the input / output buffer data file and the latency insertion method.

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Merchandiser

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The Target Brands, Inc. patent solves the following problem:

A retail store used gondola display units to organize and present merchandise to customers for purchase. A gondola display unit includes at least one base deck, a pair of pillars and a rear wall that vertically extends upward from the base deck and located between the pair of columns. The gondola display unit further includes display shelves, peg hooks, horizontal slats and others supported by the pair of columns and the back panel and presenting merchandise.

Our analysis of this patent is as follows:

Target Brands, Inc.’s patent US 9456708 B2 deals with Merchandiser.
A display apparatus includes a merchandiser box and an adapter. The merchandiser has an outer face down and an inner space defined by a back, a pair of sides, an inner bottom surface, a top and a front of a window. The empty space staff and merchandise presentation. The adapter couple behind the merchandiser box to a wall in a display instrument as external lower face of the box merchandiser revealed by general. adapter includes at least a space for receiving at least one was an exception back merchandiser box.

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Sequestration and release of carbon dioxide

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The The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin patent solves the following problem:

Our analysis of this patent is as follows:

The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin’s patent US 9457312 B2 deals with Sequestration and release of carbon dioxide.
A strategy for change capture and release carbon dioxide contained in the steps of providing a solution to a defined tetranuclear complex or mixture thereof, the adsorption sites given in coordination with solvent molecules such as water molecules. The solution is contained in the atmosphere or in a gas stream containing carbon dioxide to sequester carbon dioxide, and the pH of the resulting reaction mixture was adjusted to facilitate the release of carbon dioxide. The solution used to sequester carbon dioxide is a solution to a polynuclear transition metal compound with the formula: (I) and the tetranuclear transition metal compound that sequestered carbon dioxide is the formula: (II).

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Modified gram positive bacteria and uses thereof

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The Intrexon Actobiotics Nv patent solves the following problem:

Program-positive bacteria collectively classified as a single lipid bilayer plasma membrane. Positive bacteria program includes a multitude of bacilliform and cocciform bacterial species, among which Bifidobacteria and a group of species collectively known as lactic acid bacteria (LAB). Lab consists of a Glade of gram-positive, low-GC, acid-tolerant, generally non-sporulating, non-respiring rod or cocci that are associated by their common metabolic and physiological characteristics. These bacteria, usually found in the (decomposing) plants and dairy products, lactic acid as the major metabolic end-products of carbohydrate fermentation. This character, throughout history, lab involved with food fermentations as acidification inhibits the growth of spoilage agents. A prototype Lab Lactococcus lactis is a mesophilic microaerophilic fermenting lactic acid bacteria. While the bacteria are widely used in food fermentations, especially in the dairy industry, there is an increasing interest for use in medicines and nutraceuticals, as medicine to treat infections of bodily hole as vaginal infections, or as a carrier for the delivery of biological active molecules. In all cases, there is a need for very viable starter culture, or drug or nutraceutical formulation containing a high number of viable bacteria. L. lactis, however, tends to lose viability during storage, or during processing (for ao the production of a dry powder formulation, tablet formation, …). The drop in viability more punishment when the bacteria after LYOPHILISATION submitted further pressure as high acidity or the presence of bile salts.

Our analysis of this patent is as follows:

Intrexon Actobiotics Nv’s patent US 9458467 B2 deals with Modified gram positive bacteria and uses thereof.
The present invention relates to a program positive bacteria, preferably in a lactic acid bacteria (LAB) or Bifidobacterium, with more stress resistance and / or improved manufacturing, processing and / or storage character. In particular, the invention relates to a program positive bacteria accumulate intracellular trehalose. The program positive bacteria according to the invention lacking trehalose 6-phosphate phosphorylase (TrePP) activity. The program positive bacteria becomes more than cellobiose-specific PTS system IIC component (PTCC) activity. The program positive bacteria may further overexpress trehalose transporters. invention further relates to compositions comprising the program positive bacteria as well as methods and uses thereof.

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Therapeutic agents comprising fusions of insulin and elastic peptides

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The Duke University patent solves the following problem:

Therapeutic proteins or peptides in their native state or when recombinantly produced a labile molecules demonstrate, inter alia, short periods of serum stability, serum half-life (ie, circulation half-life ), or limited Persistance body. Such molecules can also be extremely labile when formulated, as when formulated in aqueous solution.

Our analysis of this patent is as follows:

Duke University’s patent US 9458218 B2 deals with Therapeutic agents comprising fusions of insulin and elastic peptides.
The present invention provides therapeutic agents and compositions comprising elastic therapeutic peptides and proteins. Such peptide exhibit a flexible, extended conformation. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist (eg, GLP-1, exendin), insulin, or Factor VII / VIIa, including functional analogs. The present invention further provides polynucleotides encoding, as well as methods of making and using therapeutic agents. The therapeutic agent is improvement in relationship to their use as therapeutics, including, inter alia, one or more of the half-life, clearance and / or body Persistance, solubility, and bioavailability.

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System and method for performing surgical procedures with a reusable instrument module

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The Covidien Lp patent solves the following problem:

The present disclosure relates generally to the field of reposable or reusable opera. In particular, the disclosure relates to instruments with separable and replaceable components to provide clean, sterile or renovated over time.

Our analysis of this patent is as follows:

Covidien Lp’s patent US 9456873 B2 deals with System and method for performing surgical procedures with a reusable instrument module.
A surgical instrument includes an outer housing shell defining a cavity. The outer housing shell defines an upper outer housing half and a lower outer housing of the half. The upper outer housing half defines a longitudinal axis. An instrument module is selectively insertable into the hole in the outer housing shell. The instrument module includes an inner housing shell, at least one motor disposed in the housing shell, a control board in electrical communication with at least one motor, and an energy source in electrical communication with at least one motor and the control board. The instrument module is inserted into the hole in the outer housing shell in such a way that the operative axis at least one motor that substantially parallel to the longitudinal axis on the outer half of the housing.

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Spirometry system and disposable volume spirometry apparatus

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The Stefano Soatto, , Giuseppe Torresin patent solves the following problem:

Measuring airflow and the number of regular made during clinical investigation in respiratory physiology and pathology, occupational medicine, sports medicine, allergy and immunology, respiratory function laboratory, pulmonology, as well as a variety of industrial and scientific state. Spirometry is a non-invasive approach to lung function testing that measures the amount (number) and / or speed (flow) of air that can be smoked out. Spirometry create measures that will help in assessing the situation such as asthma, chronic bronchitis, emphysema, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, cystic fibrosis, and other such lung-related conditions.

Our analysis of this patent is as follows:

Stefano Soatto, , Giuseppe Torresin’s patent US 9456768 B2 deals with Spirometry system and disposable volume spirometry apparatus.
A disposable number spirometry equipment and non-contact measuring systems are described. The spirometry system includes an expandable disposable number spirometry equipment, a remote non-contact sensor, memory, and a processor. The remote non-contact image sensor associated with the expandable disposable number spirometry apparatus. memory to store the captured images. processor operatively coupled to the memory and determines a number of expandable disposable number spirometry equipment by analyzing the captured images.

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Drink containers and cap assemblies

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The Camelbak Products, Llc patent solves the following problem:

Beverage containers come in a variety of forms and is used to carry a variety of drinks for consumption on a user. The other drinks container with an open top, and a user only involves the mouth or neck drink bottle to consume a drink from the bottle. The other drinks container with a cover that is separate from, but removably coupled to a container, with the lid with some sort of drink spout through which a drink prepared for consumption one user. The beverage containers can be in the form of sports bottles, water bottle, glasses trips, vacuum bottles, and the like. The rest of the drink container with a cap of a drink spout to be selectively opened and closed to allow a user to selectively seal and unseal the drink spout, and some drink containers, and / or caps further include a manual actuator and closure for selectively opening and closing the drink spout. If the drink containers used in beverages other than water, such as that included sugar or other suspended particulates to stick to or otherwise foul components associated with drinking fountain, actuators, or other internal components of the cap, can be difficult to clean these parts of the pulley and / or drink container.

Our analysis of this patent is as follows:

Camelbak Products, Llc’s patent US 9456710 B2 deals with Drink containers and cap assemblies.
drink bottle containing a liquid container and a cap assembly removably coupled to the liquid container. Cap assembly includes a body defining a drink outlet for dispensing liquid drink, and an operational assembly operatively coupled to the body and that there is at least an open configuration to allow liquid to drink provided and a closed configuration preventing the liquid from the drink provided. In some embodiments, the operational community that there is also a clean configuration of the operational assembly spaced from the body cap assembly for cleaning. In some embodiments, the operational community lies mostly outside the body cap assembly.

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Nucleic acid molecules encoding antibodies which bind CCR4 and uses thereof

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The Cancer Research Technology Limited patent solves the following problem:

With more than 800 members, G-protein-coupled receptor (GPCRs) represent the largest family of cell surface molecules involved in signal transmission, accounting for 2% of the total gene encoded human genome. The members of the GPCR share a common membrane Topology: an extracellular N-terminus, an intracellular C-terminus and seven transmembrane (TM) helices connected by three intracellular loops and three extracellular loops. On the basis of their shared topological structure, GPCRs are also referred to as seven transmembrane (7tm) receptor. These receptors control key physiological functions, including neurotransmission, hormone and enzyme release from endocrine and exocrine glands, immune responses, cardiac- and smooth-muscle and blood pressure regulation. Their dysfunction contributes to some of the most widespread human diseases. Emerging experimental and clinical data showed that GPCRs have an important role in cancer growth and metastasis. Therefore, the possibility exists that some GPCRs could be target for anti-cancer drugs.

Our analysis of this patent is as follows:

Cancer Research Technology Limited’s patent US 9458238 B2 deals with Nucleic acid molecules encoding antibodies which bind CCR4 and uses thereof.
The present invention provides antibodies that bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and that is capable of inhibiting the binding of macrophage-derived chemokine (MDC) and / or thymus and activation regulated chemokine (TARC) CCR4. Also provides inter alia immunoconjugates and compositions comprising these antibodies and methods and uses involving the same antibody, particularly in the medical and diagnostic fields.

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